Is Axonal Degeneration a Key Early Event in Parkinson's Disease?
Identifieur interne : 000308 ( Main/Exploration ); précédent : 000307; suivant : 000309Is Axonal Degeneration a Key Early Event in Parkinson's Disease?
Auteurs : Zuzanna Kurowska [États-Unis] ; Jeffrey H. Kordower [États-Unis] ; A Jon Stoessl [Canada] ; Robert E. Burke [États-Unis] ; Patrik Brundin [États-Unis] ; Zhenyu Yue [États-Unis] ; Scott T. Brady [États-Unis] ; Jeffrey Milbrandt [États-Unis] ; Bruce D. Trapp [États-Unis] ; Todd B. Sherer [États-Unis] ; Satish Medicetty [États-Unis]Source :
- Journal of Parkinson's disease [ 1877-718X ] ; 2016.
Abstract
Recent research suggests that in Parkinson's disease the long, thin and unmyelinated axons of dopaminergic neurons degenerate early in the disease process. We organized a workshop entitled 'Axonal Pathology in Parkinson's disease', on March 23rd, 2016, in Cleveland, Ohio with the goals of summarizing the state-of-the-art and defining key gaps in knowledge. A group of eight research leaders discussed new developments in clinical pathology, functional imaging, animal models, and mechanisms of degeneration including neuroinflammation, autophagy and axonal transport deficits. While the workshop focused on PD, comparisons were made to other neurological conditions where axonal degeneration is well recognized.
DOI: 10.3233/JPD-160881
PubMed: 27497486
Affiliations:
- Canada, États-Unis
- Illinois, Massachusetts, Michigan, Missouri (État), Ohio, État de New York
- Chicago
- Université de l'Illinois à Chicago
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Burke</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Neurology and Pathology & Cell Biology, Columbia University Medical Center, New York City, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Pathology & Cell Biology, Columbia University Medical Center, New York City, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Brundin, Patrik" sort="Brundin, Patrik" uniqKey="Brundin P" first="Patrik" last="Brundin">Patrik Brundin</name><affiliation wicri:level="2"><nlm:affiliation>Van Andel Research Institute, Center for Neurodegenerative Science, Grand Rapids, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Van Andel Research Institute, Center for Neurodegenerative Science, Grand Rapids, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Yue, Zhenyu" sort="Yue, Zhenyu" uniqKey="Yue Z" first="Zhenyu" last="Yue">Zhenyu Yue</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Departments of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Brady, Scott T" sort="Brady, Scott T" uniqKey="Brady S" first="Scott T" last="Brady">Scott T. Brady</name><affiliation wicri:level="4"><nlm:affiliation>Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, USA; Marine Biological Laboratory, Woods Hole, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, USA; Marine Biological Laboratory, Woods Hole, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region><settlement type="city">Chicago</settlement></placeName><orgName type="university">Université de l'Illinois à Chicago</orgName></affiliation></author><author><name sortKey="Milbrandt, Jeffrey" sort="Milbrandt, Jeffrey" uniqKey="Milbrandt J" first="Jeffrey" last="Milbrandt">Jeffrey Milbrandt</name><affiliation wicri:level="2"><nlm:affiliation>Department of Genetics, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; Hope Center for Neurological Disorders, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Genetics, Washington University School of Medicine in St. Louis, St. Louis, MO, USA; Hope Center for Neurological Disorders, Washington University School of Medicine in St. Louis, St. Louis, MO</wicri:regionArea><placeName><region type="state">Missouri (État)</region></placeName></affiliation></author><author><name sortKey="Trapp, Bruce D" sort="Trapp, Bruce D" uniqKey="Trapp B" first="Bruce D" last="Trapp">Bruce D. Trapp</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Sherer, Todd B" sort="Sherer, Todd B" uniqKey="Sherer T" first="Todd B" last="Sherer">Todd B. Sherer</name><affiliation wicri:level="2"><nlm:affiliation>The Michael J. Fox Foundation for Parkinson's Research, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The Michael J. Fox Foundation for Parkinson's Research, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Medicetty, Satish" sort="Medicetty, Satish" uniqKey="Medicetty S" first="Satish" last="Medicetty">Satish Medicetty</name><affiliation wicri:level="2"><nlm:affiliation>Renovo Neural Inc., Cleveland, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Renovo Neural Inc., Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author></analytic><series><title level="j">Journal of Parkinson's disease</title><idno type="eISSN">1877-718X</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Recent research suggests that in Parkinson's disease the long, thin and unmyelinated axons of dopaminergic neurons degenerate early in the disease process. We organized a workshop entitled 'Axonal Pathology in Parkinson's disease', on March 23rd, 2016, in Cleveland, Ohio with the goals of summarizing the state-of-the-art and defining key gaps in knowledge. A group of eight research leaders discussed new developments in clinical pathology, functional imaging, animal models, and mechanisms of degeneration including neuroinflammation, autophagy and axonal transport deficits. While the workshop focused on PD, comparisons were made to other neurological conditions where axonal degeneration is well recognized.</div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Illinois</li><li>Massachusetts</li><li>Michigan</li><li>Missouri (État)</li><li>Ohio</li><li>État de New York</li></region><settlement><li>Chicago</li></settlement><orgName><li>Université de l'Illinois à Chicago</li></orgName></list><tree><country name="États-Unis"><region name="Ohio"><name sortKey="Kurowska, Zuzanna" sort="Kurowska, Zuzanna" uniqKey="Kurowska Z" first="Zuzanna" last="Kurowska">Zuzanna Kurowska</name></region><name sortKey="Brady, Scott T" sort="Brady, Scott T" uniqKey="Brady S" first="Scott T" last="Brady">Scott T. Brady</name><name sortKey="Brundin, Patrik" sort="Brundin, Patrik" uniqKey="Brundin P" first="Patrik" last="Brundin">Patrik Brundin</name><name sortKey="Burke, Robert E" sort="Burke, Robert E" uniqKey="Burke R" first="Robert E" last="Burke">Robert E. Burke</name><name sortKey="Kordower, Jeffrey H" sort="Kordower, Jeffrey H" uniqKey="Kordower J" first="Jeffrey H" last="Kordower">Jeffrey H. Kordower</name><name sortKey="Medicetty, Satish" sort="Medicetty, Satish" uniqKey="Medicetty S" first="Satish" last="Medicetty">Satish Medicetty</name><name sortKey="Milbrandt, Jeffrey" sort="Milbrandt, Jeffrey" uniqKey="Milbrandt J" first="Jeffrey" last="Milbrandt">Jeffrey Milbrandt</name><name sortKey="Sherer, Todd B" sort="Sherer, Todd B" uniqKey="Sherer T" first="Todd B" last="Sherer">Todd B. Sherer</name><name sortKey="Trapp, Bruce D" sort="Trapp, Bruce D" uniqKey="Trapp B" first="Bruce D" last="Trapp">Bruce D. Trapp</name><name sortKey="Yue, Zhenyu" sort="Yue, Zhenyu" uniqKey="Yue Z" first="Zhenyu" last="Yue">Zhenyu Yue</name></country><country name="Canada"><noRegion><name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A Jon" last="Stoessl">A Jon Stoessl</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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